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While the symp- 136 GALE ENCYCLOPEDIA OF ALTERNATIVE MEDICINE 2 toms may be similar cheap 20 mg tastylia fast delivery, certain important aspects of asthma are different in children and adults. When asthma begins INHALED ALLERGENS in childhood, it often does so in a child who is likely, for MOST OFTEN TRIGGERING ASTHMA ATTACKS genetic reasons, to become sensitized to common aller- gens in the environment. In 2004, scientists in Helsinki, Finland, Animal dander identified two new genes that cause atopic asthma. The discovery might lead to earlier prediction of asthma in Cockroach allergens children and adults. When these children are exposed to Dust mites dust, animal proteins, fungi, or other potential allergens, Indoor fungi (molds) they produce a type of antibody that is intended to engulf and destroy the foreign materials. This has the effect of Occupational allergens such as chemicals, fumes, particles of industrial materials making the airway cells sensitive to particular materials. This condition of atopy is present in at least one third and as many as one half of the general population. When an infant or young child wheezes during viral in- • cockroach allergens fections, the presence of allergy (in the child or a close • pollen relative) is a clue that asthma may well continue throughout childhood. Many adults who are • air pollutants not allergic have such conditions as sinusitis or nasal In addition, there are three important factors that polyps, or they may be sensitive to aspirin and related regularly produce attacks in certain asthmatic patients, drugs. Another major source of adult asthma is exposure and they may sometimes be the sole cause of symptoms. Besides wheezing and minimizing) exposure is the most effective way of treat- being short of breath, the patient may cough or report a ing asthma, it is vital to identify which allergen or irri- feeling of tightness in the chest. Wheez- asthma is present, symptoms can be set off or made ing often is loudest when the patient exhales. Some asth- worse if the patient also has rhinitis (inflammation of matics are free of symptoms most of the time but may the lining of the nose) or sinusitis. Others son, stomach acid passes back up the esophagus in a re- spend much of their days (and nights) coughing and action called acid reflux, this condition also can make wheezing until properly treated.

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ELISA results then are tested with a Western blot or im- munofluorescence (IFA) assay for confirmation order tastylia 20mg with amex. The A report released in 2003 showed trends in in- combination of the ELISA and Western blot tests is more creased use of alternative medicine among HIV-positive than 99. The polymerase that 79% of those seeking alternative therapy to help chain reaction (PCR) test can be used to detect the pres- with AIDS treatment or symptom relief were men and ence of viral nucleic acids in the very small number of 63% were women. The types of therapies they used most HIV patients who have false-negative results on the were relaxation techniques, massage, chiropractic care, ELISA and Western blot tests. However, fur- Supplements ther research was ongoing as to its effectiveness in re- • Lauric oils (coconut oil) are used by the body to make placing current tests as a first check for HIV. One study found that 250 micro- mended dose is one quarter to one half teaspoon twice grams of selenomethionin daily for one year showed no daily improvement in CD4 cell counts or disease symptoms. One study found Health study cautioned that garlic supplements could that DHEA had no effect on lymphocytes or p24 anti- reduce levels of a protease inhibitor that is used to treat gen levels. However, a 2002 study found that it was as- AIDS patients, so patients should discuss using garlic sociated with a significant increase in measures that in- supplements with their physicians. One study of pregnant women with AIDS found able as soap, dental floss, toothpick, and mouthwash. Another study that patients who use marijuana had increased food in- found that 60 mg of vitamin A had no effect on CD4 take and weight gain. Vitamin A has been associated with tetrahydrocannabinol is licensed for treating AIDS faster disease progression. Beta-carotene supplementation has led tal state can have a direct impact on disease severity and to elevation in white blood cell counts and changes in quality of life. These include: carotene supplementation led to an increase in deaths • massage due to cancer and heart disease. AIDS pa- Antiretroviral treatment tients took a tablet that contained 31 herbs that was In recent years researchers have developed drugs based on the formulas Enhance and Clear Heat.

In addition purchase 20mg tastylia, buspirone does not R 6 5 4 7 N potentiate the central nervous system depression caused by sedative–hypnotic drugs or by alcohol, and it R4 does not prevent the symptoms associated with benzo- R2′ diazepine withdrawal. Clinical Uses 1,4-Benzodiazepine nucleus Buspirone is effective in general anxiety and in anxiety FIGURE 30. The inverse agonists Sedative–Hypnotic and are compounds that interact with benzodiazepine re- Anxiolytic Drugs ceptors and decrease, rather than increase, GABA- mediated changes. They also can antagonize the effects Drugs Therapeutic Uses of benzodiazepine agonists and when administered alone, can be anxiogenic and proconvulsant. Alprazolam (Xanax) Anxiety Buspirone (BuSpar) Anxiety Chloral hydrate (Noctec, Somnos) Insomnia Pharmacokinetics Chlordiazepoxide (Librium) Anxiety, alcohol with- drawal Benzodiazepines are usually given orally and are well Chlorazepate (Tranxene) Anxiety absorbed by this route. Since the benzodiazepines are Diazepam (Valium) Anxiety, muscle relax- ation, status epilepticus weak bases, they are less ionized in the relatively alka- Flurazepam (Dalmane) Insomnia line environment of the small intestine, and therefore, Flumazenil (Romazicon) Reverse benzodiazepine- most of their absorption takes place at this site. For induced sedation emergency treatment of seizures or when used in anes- Hydroxyzine (Atarax, Vistaril) Anxiety thesia, the benzodiazepines also can be given parenter- Lorazepam (Ativan) Anxiety Midazolam (Versed) Anesthesia ally. Prazepam (Centrax) Anxiety The distribution of the benzodiazepines from blood Propranolol (Inderal) Anxiety to tissues and back again is a dynamic process with con- Temazepam (Restoril) Insomnia siderable influence on the onset and duration of the Triazolam (Halcion) Insomnia Zolpidem (Ambien) Insomnia therapeutic effects produced by these compounds. Zaleplon (Sonata) Insomnia Those having greater lipid solubility tend to enter the central nervous system more rapidly and thus tend to produce their effects more quickly. Several of the ben- zodiazepines have therapeutic effects that are much acid (GABA), which is the major inhibitory neurotrans- shorter in duration than would be predicted based on mitter in the mammalian brain. Benzodiazepines poten- their rates of metabolism and excretion; redistribution tiate GABAergic neurotransmission in essentially all away from the central nervous system is of primary im- areas of the central nervous system. The in- Metabolism takes place both by dealkylation (phase 1) crease in chloride conductance mediated by GABA is and conjugation (phase 2) reactions. This facilitation of dealkylation can result in the formation of pharmaco- GABA-induced chloride conductance results in greater logically active compounds. Indeed, most clinically avail- hyperpolarization of these cells and therefore leads to able benzodiazepines are converted in the liver to one or diminished synaptic transmission.


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